Mothabeng David Phoshoko was born on the 19 June 1945 in Wonderboom, Pretoria. With the forced removals in 1959, he and his family resettled in the town of De Wildt, and would eventually come to reside in Ga-Rankua in 1962. In the 1970s, Phoshoko and other artists began trading works with diplomats staying in the country. This patronage was fundamental to establishing Phoshoko and his fellow artists. His first solo exhibition was held in 1976, at the Nedbank Centre in Pretoria, and in 1978 he exhibited in West Germany.
Phoshoko and other black artists were committed to exposing the works of black struggles artists who were their contemporaries.
When Poshoko's own township came under the homeland government of Bophuthatswana, he began spearheading a drive to start and sustain art and craft centers in the area.